 | Anne Archer | as | Gail Weston |
| Terry Jastrow | as | John Taylor | |
 | Noah Beery, Jr. | as | Joe Locker |
 | Richard Farnsworth | as | Frank Walker |
 | Mary Kay Place | as | Kit Peabody |
| Josh Taylor | as | Luke | |
 | Ben Piazza | as | Bill Wrather |
| Jorge Cervera Jr. | as | Raoul | |
| Savannah Smith Boucher | as | Molesta Davis |
 | Robert De Niro | as | Rupert Pupkin |
 | Jerry Lewis | as | Jerry Langford |
| Diahnne Abbott | as | Rita Keane | |
 | Sandra Bernhard | as | Masha |
 | Shelley Hack | as | Cathy Long |
| Ed Herlihy | as | Ed Herlihy | |
| Lou Brown | as | Band leader | |
| Loretta Tupper | as | Stage Door Fan | |
| Peter Potulski | as | Stage Door Fan | |
| Vinnie Gonzales | as | Stage Door Fan |
 | Ray Sharkey | as | Byron Levin |
 | Ornella Muti | as | Catherine Stockheinz |
 | Klaus Kinski | as | Frederic Stockheinz |
 | Armand Assante | as | Lorenzo Prado |
 | King Vidor | as | Walter Klein |
| Susan Heldfond | as | Vicky | |
 | William Prince | as | Paultz |
 | Tony Sirico | as | Raoul (as Anthony Sirico) |
 | Jacqueline Brookes | as | Mrs. Paultz |
| Daniel Faraldo | as | Hector |
 | Peter Coyote | as | Rex |
| Jim Haynie | as | Carl / Tommy / Optometrist | |
 | Danny Glover | as | Jojo / Roland |
 | Scott Beach | as | Sailor |
 | Tippi Hedren | as | Elizabeth Morgan |
 | Faye Grant | as | Joanna Morgan |
 | Leslie Nielsen | as | Reece Morgan |
 | Barry Van Dyke | as | Linc Wilder |
| Lara Parker | as | Rachel Parmelee |
 | Diane Lane | as | Corinne Burns |
 | Ray Winstone | as | Billy - Vocals for The Looters |
 | Peter Donat | as | Harley Dennis |
 | David Clennon | as | Dave Robell - The Agent |
| John Lehne | as | Stu McGrath | |
 | Cynthia Sikes | as | Alicia Meeker |
 | Laura Dern | as | Jessica McNeil |
| Paul Cook | as | danny - Drummer for The Looters | |
| Steve Jones | as | Steve - Guitarist for The Looters | |
| Barry Ford | as | Lawnboy | |
| Paul Simonon | as | Johnny - Bassist for The Looters | |
| Fee Waybill | as | Lou Corpse - Vocals for The Metal Corpses | |
 | Christine Lahti | as | Aunt Linda |
 | Janet Wright | as | Brenda |
 | E.G. Daily | as | Motel Maid |
 | Debbie Rochon | as | Skunkette |
 | Brent Spiner | as | Corinne's Boss |
